Prof. Dr. Karsten Seeger

Photo of Karsten Seeger




Gebäude 61, Raum 323

Email: karsten.seeger(at)uni-luebeck.de
Phone: +49 451 3101-3334

Research

Detailed information about my research interests can be found here.

CV

1998-2003 Studies of Biochemistry at the Universität Leipzig
2003-2006 PhD studies, Universität Leipzig including a three month research stay at the University of Alberta (Canada)
2006-2008 Postdoctoral fellow, CEA
2008-2015 Assistant professor in "Structural biology of Autoimmunity“ at the Universität zu Lübeck
since 2015 Scientific assistant, programm coordinator of the bachelor study "Medizinische Ernährungswissenschaft"
since 10/2016 Privatdozent at the Universität zu Lübeck

Publications

  1. Gebauer JM, Flachsenberg F, Windler C, Richer B, Baumann U and Seeger K.: Structural and biophysical characterization of the type VII collagen vWFA2 subdomain leads to identification of two binding sites. FEBS Open Bio 2020 10(4): 580-592. DOI 10.1002/2211-5463.12807
  2. Hirose M, Schilf P, Zarse K, Busch H, Fuellen G, Jöhren O, Köhling R , König IR, Richer B, Rupp J, Schwaninger M, Seeger K, Sina C, Ristow M, Ibrahim SM.: Maternally inherited diff erences within mitochondrial complex I control murine healthspan. Genes 2019 10(7), 532. DOI: 10.3390/genes10070532
  3. Depping R, Seeger K.: 1H-NMR spectroscopy shows cellular uptake of HEPES buffer by human cell lines—an effect to be considered in cell culture experiments. Analytical and Bioanalytical Chemistry 2019 411(4):797-802. DOI: 10.1007/s00216-018-1518-4
  4. Richer BC, Salei N, Laskay T, Seeger K.: Changes in neutrophil metabolism upon activation and aging. Inflammation 2018 41(2): 710-721. DOI: 10.1007/s10753-017-0725-z
  5. Windler C, Gey C, Seeger K.: Skin melanocytes and fibroblasts show different changes in choline metabolism during cellular senescence. Mech Ageing Dev 2017 164:82-90. DOI: 10.1016/j.mad.2017.05.001
  6. Windler C, Hermsdorf U, Brinckmann J, Seeger K.: A type VII collagen subdomain mutant is thermolabile and shows enhanced proteolytic degradability – implications for the pathogenesis of recessive dystrophic epidermolysis bullosa?, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2017 1863: 52-59. DOI: 10.1016/j.bbadis.2016.10.023
  7. Hermsdorf U, Seeger K.: Chemical shift assignments of the fibronectin III like domains 7-8 of type VII collagen. Biomol NMR Assign 2016 10: 53-55. DOI: 10.1007/s12104-015-9636-9
  8. Iwata H, Witte M, Samavedam UK, Gupta Y, Shimizu A, Ishiko A, Schröder T, Seeger K, Dahlke M, Rades D, Zillikens D, Ludwig RJ.: Radiosensitive hematopoietic cells determine the extent of skin inflammation in experimental epidermolysis bullosa acquisita. J Immunol. 2015, 195(5):1945-54. DOI: 10.4049/jimmunol.1501003
  9. Kemmer A, Bieber K, Abadpour A, Yu X, Mitschker N, Roth S, Kauderer C, Ludwig R, Seeger K, Köhl J, Zillikens D, Recke A.: Drugs from bugs: recombinant neutrophil inhibitory factor (NIF) impairs the activation of human neutrophils. Exp Dermatol. 2015; DOI: 10.1111/exd.12804
  10. Richer BC, Seeger K.: The hinge region of type VII collagen is intrinsically disordered. Matrix Biol. 2014, 36: 77-83. DOI: 10.1016/j.matbio.2014.04.006
  11. Wegener H, Paulsen H, Seeger K.: The cysteine rich region oftype VII collagen is a cystine knot with a new topology. J Biol Chem. 2014, 289(8): 4861-4869. DOI: 10.1074/jbc.M113.531327
  12. Iwata H, Bieber K, Tiburzy B, Chrobok N, Kalies K, Shimizu A, Leineweber S, Ishiko A, Vorobyev A, Zillikens D, K hl J, Westermann J, Seeger K, Manz R, Ludwig RJ.: B Cells, Dendritic Cells, and Macrophages Are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisita. J Immunol. 2013, 191(6): 2978-2988. DOI: 10.4049/jimmunol.1300310
  13. Schönig S, Recke A, Hirose M, Ludwig R, Seeger K.: Metabolite analysis distinguishes between mice with epidermolysis bullosa acquisita and healthy mice. Orphanet Journal of Rare Diseases 2013, 8(1):93. DOI: 10.1186/1750-1172-8-93
  14. Gey C, Seeger K.: Metabolic changes during cellular senescence investigated by proton NMR-spectroscopy. Mech Ageing Dev 2013, 134(3-4): 130-138. DOI: 10.1016/j.mad.2013.02.002
  15. Wegener H, Leineweber S, Seeger K.: The vWFA2 domain of type VII collagen is responsible for collagen binding. Biochem Biophys Res Commun 2013, 430(2): 449-453. DOI: 10.1016/j.bbrc.2012.11.119
  16. Jiao Y*, Seeger K*, Lautrette A, Gaubert A, Mousson F, Guerois R, Mann C, Ochsenbein F: Surprising complexity of the Asf1 histone chaperone-Rad53 kinase interaction and its differential modulation in response to genotoxic stress. PNAS 2012; 109(8): 2866-2871. DOI: 10.1073/pnas.1106023109, * joint first authorship
  17. Leineweber S, Schönig S, Seeger K.: Insight into interactions of the von-Willebrand-factor-A-like domain 2 with the FNIII like domain 9 of collagen VII by NMR and SPR. FEBS Lett 2011, 585: 1748-1752. DOI: 10.1016/j.febslet.2011.04.071
  18. Seeger K, Lein S, Reuter G, Berger S.:Saturation Transfer Difference Measurements with SU(VAR)3-9 and S-adenosyl-L-methionine. Biochemistry 2005; 44(16): 6208-6213. DOI: 10.1021/bi047749x
  19. Pagel K, Seeger K, Seiwert B, Villa A, Mark AE, Berger S, Koksch B.: Advanced approaches for the characterization of a de novo designed antiparallel coiled coil peptide. Org Biomol Chem 2005; 3(7): 1189-1194. DOI: 10.1039/b418167k
  20. Peikert C, Seeger K, Bhat RK, Berger S.:Determination of the binding specificity of the 12S subunit of the transcarboxylase by saturation transfer difference NMR. Org Biomol Chem 2004; 2(12): 1777-1781. DOI: 10.1039/b404238g

 

review articles/book chapters:

  1. Seeger K.: Metabolic changes in autoimmune diseases. In Curr. Drug Discov. Technol. 6 (2009), 256-261. DOI: 10.2174/157016309789869074
  2. Gey, C. and Seeger, K., 2017. Metabolic changes investigated by proton NMR spectroscopy in cells undergoing oncogene-induced senescence, in: Nikiforov, M.A. (Ed.), Oncogene-Induced Senescence: Methods and Protocols. Springer New York, New York, NY, pp. 155-163. DOI: 10.1007/978-1-4939-6670-7_15