Theses

At the Institute of Chemistry and Metabolomics you can write bachelor and master theses. Just get in touch with us.

General topics

• Metabolomics method development
• Analysis of blood samples in the context of medical studies
• Metabolicch flux analysis in cells
• Glycoprotein analysis in blood samples

Measurement techniques

• High-resolution NMR spectroscopy: protein-ligand interactions with atomic resolution, dynamics of biological macromolecules
• NMR methods for metabolomics and metabolic flux analysis
• Identification of new biomarkers for different clinical cohorts via statistical analysis
• Development of algorithms and software development for NMR proteo-metabolomics via Matlab
• Deciphering the NMR signatures of different sample materials
• General laboratory methods: Protein purification, gel electrophoresis and Western blots, chromatography, sample preparation, protein expression (isotope labeled), 1D and 2D NMR spectroscopy, mass spectrometry

Past bachelor and master theses

• Metabolic profiling of black and white pepper (piper nigrum L.) based on 1H-NMR-spectroscopy for geographical discrimination and analysis of tentative metabolomic fingerprints of the non volatile metabolome. (2023)
  Study program MLS Bachelor
  Supervised by Prof. Dr. Ulrich Günther

• Metabolic Profile Analysis of an Omnivorous and Vegetarian Diet using 1H-Nuclear Magnetic Resonance Spectroscopy on Human Faeces Samples. (2022)
  Study program MEW, Bachelor
  Supervised by Prof. Dr. Ulrich Günther

• Analysis of edible Oils via one-dimensional 1H- and 13C-Nuclear Magnetic Resonance Spectroscopy. (2022)
  Study programg Biophysics Bachelor
  Supervised by Prof. Dr. Ulrich Günther

• Investigation on Serum Lipoproteins using NMS-Spectroscopy. (2021)
  Study program MLS Bachelor
  Supervised by Prof. Dr. Ulrich Günther

• Unravelling the NMR Signatures of Glycoproteins from Human Blood: Isolation and Characterisation of Native Serum Glycoproteins. (2023)
  Studiengang MLS, Bachelor
  Betreut durch  Dr. Alvaro Mallagaray
  Mit Unterstützung von Lorena Rudolph

• Assignment of an NMR Library of N-glycans and Development of New Tools for Their Application in Proteometabolomics. (2023)
  Study program MLS, Bachelor
  Supervised by Dr. Alvaro Mallagaray

• Towards better quantification of blood metabolites using T2-filtered NMR-Spectroscopy. (2023)
  Study program MLS, Bachelor
  Supervised by Dr. Alvaro Mallagaray

• Development of an NMR-based method for the quantification of acute-phase proteins from serum samples. (2022)
  Study program MLS, Master
  Supervised by Dr. Alvaro Mallagaray

• Quantification of Glycoproteins in Human Serum by Identification of selective N-Glycan Signals in onedimensional 1H-Nuclear Magnetic Resonance Spectra using Univariate Analyses. (2022) 
  Study program MLS, Bachleor
  Supervised by Dr. Alvaro Mallagaray

• Study of the interaction of Endo-β-N-acetylglucosaminidases with complex carbohydrates by NMR spectroscopy. (2020)
  Study program MLS, Bachelor
  Supervised by Dr. Alvaro Mallagaray